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Key Documents

O5504

Sigma-Aldrich

Oleanolic acid

≥97%

Sinonimo/i:

(+)-Oleanolic acid, 3beta-Hydroxyolean-12-en-28-oic acid, Astrantiagenin C, Caryophyllin, Oleanic acid

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About This Item

Formula empirica (notazione di Hill):
C30H48O3
Numero CAS:
Peso molecolare:
456.70
Numero CE:
Numero MDL:
Codice UNSPSC:
12352002
ID PubChem:
NACRES:
NA.22

Livello qualitativo

Saggio

≥97%

Forma fisica

powder

Colore

light yellow

Punto di fusione

>300 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

[H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
MIJYXULNPSFWEK-GTOFXWBISA-N

Informazioni sul gene

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Descrizione generale

Oleanolic acid is a hydroxyl pentacyclic triterpenoic acid (HPTA), which exhibits antibacterial, antitumor and antileishmanial activity.

Applicazioni

Oleanolic acid has been used as a reference compound during its quantification in the roots of Cissampelos pareria Linn.var hirsuta by high performance thin layer chromatography (HPTLC).

Azioni biochim/fisiol

Triterpenoid isolated from medicinal plants. Antitumor and hepatoprotective agent. Oleanolic acid has therapeutic potential for neurodegenerative diseases.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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Sigma-Aldrich

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Ursolic acid primary reference standard

03240595

Ursolic acid

Phytolaccagenin phyproof® Reference Substance

PHL80614

Phytolaccagenin

Ursolic Acid A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.

Sigma-Aldrich

672315

Ursolic Acid

NDB ≥98% (HPLC)

Sigma-Aldrich

SML1604

NDB

Apurva Bhave et al.
Journal of food and drug analysis, 25(3), 681-690 (2017-09-16)
In this study, an in-depth analysis of the unique set of rosehip samples from 71 Rosa genotypes was conducted with the aim to identify the most suitable ones for applications in the food and pharmaceutical industries based on the content
Validated HPTLC method for qualitative and quantitative estimation of oleanolic acid in roots of Cissampelos pareira Linn. var. hirsuta, Menispermaceae.
Patel VG, et al.
Der Pharmacia Lettre, 7(5), 300-306 (2015)
Oleanolic acid (OA) as an antileishmanial agent: Biological evaluation and in silico mechanistic insights.
Melo TS, et al.
Parasitology International, 65(3), 227-237 (2016)
Li Chen et al.
Journal of medicinal chemistry, 51(15), 4834-4838 (2008-07-05)
Novel furoxan-based nitric oxide (NO) releasing derivatives of oleanolic acid (OA) were synthesized for potential therapy of liver cancers. Six compounds produced high levels of NO in human hepatocellular carcinoma (HCC) cells and exhibited strong cytotoxicity selectively against HCC in
Amélia M Silva et al.
Pharmaceutics, 11(8) (2019-07-28)
Oleanolic (OA) and ursolic (UA) acids are recognized triterpenoids with anti-cancer properties, showing cell-specific activity that can be enhanced when loaded into polymeric nanoparticles. The cytotoxic activity of OA and UA was assessed by Alamar Blue assay in three different

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