Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

• Sinonimo/i: 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• Formula empirica (notazione di Hill): C₂₃H₃₀ClN₃O · 2HCl
• Numero CAS: 69-05-6
• Peso molecolare: 472.88
• Beilstein: 4834013
• Numero CE: 200-700-8
• Numero MDL: MFCD00012659
• Codice UNSPSC: 12352101
• ID PubChem: 24278192
• NACRES: NA.77

Proprietà

• product name: Quinacrine dihydrochloride, ≥90%
• Origine biologica: synthetic
• Saggio: ≥90%
• Forma fisica: powder
• Punto di fusione: 257 °C
• Solubilità: H₂O: soluble, clear to hazy
• Ideatore: Bayer
• Stringa SMILE: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H; UDKVBVICMUEIKS-UHFFFAOYSA-N
• Informazioni sul gene: human ... MAOA(4128) , MAOB(4129)

Descrizione

Descrizione generale

Quinacrine is an acridine derivative and a potent antimalarial agent.

Applicazioni

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Azioni biochim/fisiol

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

Caratteristiche e vantaggi

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Stoccaggio e stabilità

Stock solutions are stable for up to 60 h at 20°C.

Altre note

This product is not assigned an expiration date or recommended retest date.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves