P8953

Platelet-Derived Growth Factor from porcine platelets

PDGF, lyophilized powder, suitable for cell culture

• Sinonimo/i: PDGF
• Numero MDL: MFCD00166903
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Origine biologica: Porcine
• Livello qualitativo: 200
• Saggio: ≥97% (SDS-PAGE and N-terminal analysis)
• Stato: lyophilized powder
• Potenza: 39.00 ng/mL EC₅₀
• Qualità: endotoxin tested
• PM: glycoprotein 38 kDa
• Confezionamento: pkg of 5 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• tecniche: cell culture | mammalian: suitable

Descrizione

Applicazioni

PDGF elicits multifunctional actions with a variety of cells, including mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts.

Azioni biochim/fisiol

The principal mitogen found in mammalian serum, released from platelets during clot formation. Elicits mitogenesis of mesoderm-derived cells, increased extracellular matrix synthesis, and chemotaxis and activation of neutrophils, monocytes and fibroblasts. Mitogenic for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. Appears to interact with transforming growth factor-β1 in accelerating wound healing. However, platelet-derived growth factor (PDGF) may also be pathogenic in arteriosclerosis and neoplasia.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid, pH 2.0.

Risultati analitici

The mitogenic activity is tested in culture using Swiss 3T3 cells or NR6-3T3 fibroblasts.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)