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P8477

Sigma-Aldrich

Picotamide

Sinonimo/i:

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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About This Item

Formula empirica (notazione di Hill):
C21H20N4O3
Numero CAS:
32828-81-2
Peso molecolare:
376.41
Numero CE:
251-245-7
Numero MDL:
MFCD00866792
Codice UNSPSC:
12352204
ID PubChem:
24278656
NACRES:
NA.83

Saggio

≥98%

Livello qualitativo

100

Stato

powder

Solubilità

ethanol: 50 mg/mL, clear, colorless to light yellow

Stringa SMILE

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
KYWCWBXGRWWINE-UHFFFAOYSA-N

Informazioni sul gene

human ... TBXA2R(6915)

Azioni biochim/fisiol

Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCF5004
MKBW5293V
SLBG4024V
SLBF6109V
SLBC8317V

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P Mura et al.
Drug development and industrial pharmacy, 24(8), 747-756 (1999-01-07)
The potential compatibilities of several commonly used pharmaceutical excipients with picotamide were evaluated using differential scanning calorimetry (DSC). The effects of aging and of mechanical treatment (blending, grinding, or kneading) of samples were also evaluated. Hot-stage microscopy (HSM) and scanning
Martin Hennenberg et al.
American journal of physiology. Renal physiology, 305(10), F1383-F1390 (2013-09-21)
Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of
R Vezza et al.
Thrombosis and haemostasis, 78(5), 1385-1391 (1998-01-04)
Picotamide is a dual thromboxane (Tx) A2 receptor antagonist/Tx synthase inhibitor although some observations suggest an anti-vasoconstrictor effect independent of TxA2 inhibition/antagonism. The aim of our study was to assess whether picotamide antagonises vascular contractions induced by different vasoactive substances
S Ratti et al.
European journal of pharmacology, 355(1), 77-83 (1998-10-01)
Picotamide is an antiplatelet drug with a peculiar dual mechanism of action: it inhibits thromboxane A2 synthase and antagonizes the pharmacological responses mediated by thromboxane A2 receptor. We investigated the in vitro effect of picotamide on smooth muscle cell migration
Carola Buccellati et al.
European journal of pharmacology, 443(1-3), 133-141 (2002-06-05)
We evaluated the capacity of anti-aggregating agents to influence thromboxane A(2) and prostacyclin formation, arachidonic acid-endoperoxide redirection, platelet aggregation and vessel tone, in isolated rabbit aorta incubated with homologous platelets. Picotamide (N,N'bis(3-pyridinylmethyl)-4-methoxy-isophthalamide), the only dual thromboxane A(2)-synthase inhibitor/receptor antagonist in
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