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P4620

Sigma-Aldrich

PD 146176

≥98% (HPLC), solid

Sinonimo/i:

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

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About This Item

Formula empirica (notazione di Hill):
C15H11NS
Numero CAS:
4079-26-9
Peso molecolare:
237.32
Numero MDL:
MFCD05664738
Codice UNSPSC:
51111800
ID PubChem:
24724579
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white to beige

Solubilità

DMSO: soluble >10 mg/mL
H2O: insoluble

Stringa SMILE

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Informazioni sul gene

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Applicazioni

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Azioni biochim/fisiol

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Erastin ≥98% (HPLC)

Sigma-Aldrich

E7781

Erastin

Deferoxamina powder, ≥92.5% (TLC)

Sigma-Aldrich

D9533

Deferoxamina

Jiang Yang et al.
Scientific reports, 9(1), 13316-13316 (2019-09-19)
Ovarian cancer (OvCa), while accounting for only 3% of all women's cancer, is the fifth leading cause of cancer death among women. One of the most significant obstacles to successful OvCa treatment is chemoresistance. The current lack of understanding of
David M Tobin et al.
PloS one, 8(7), e67828-e67828 (2013-07-23)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here
Yoo Jin Na et al.
Cancers, 11(11) (2019-11-14)
Despite the importance of radiation therapy, there are few radiation-related markers available for use in clinical practice. A larger catalog of such biomarkers is required to help clinicians decide when radiotherapy should be replaced with a patient-specific treatment. Arachidonate 15-lipoxygenase
Manuela Schneider et al.
Neoplasia (New York, N.Y.), 12(3), 254-263 (2010-03-18)
The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and created
Haider H Dar et al.
The Journal of clinical investigation, 128(10), 4639-4653 (2018-09-11)
Ferroptosis is a death program executed via selective oxidation of arachidonic acid-phosphatidylethanolamines (AA-PE) by 15-lipoxygenases. In mammalian cells and tissues, ferroptosis has been pathogenically associated with brain, kidney, and liver injury/diseases. We discovered that a prokaryotic bacterium, Pseudomonas aeruginosa, that

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