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K3888

Sigma-Aldrich

Kenpaullone

≥98%

Sinonimo/i:

9-Bromo-7,12-dihydro-indolo­[3,2-d]­[1]benzazepin-6(5H)-one, NSC 664704

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About This Item

Formula empirica (notazione di Hill):
C16H11BrN2O
Numero CAS:
142273-20-9
Peso molecolare:
327.18
Numero MDL:
MFCD02683595
Codice UNSPSC:
12352200
ID PubChem:
24278507
NACRES:
NA.77

Saggio

≥98%

Stato

solid

Colore

yellow

Solubilità

DMSO: 18 mg/mL, clear, yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI

1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
QQUXFYAWXPMDOE-UHFFFAOYSA-N

Informazioni sul gene

human ... CDC2(983)
mouse ... Gsk3b(56637)
rat ... Gsk3b(84027)

Categorie correlate

Applicazioni

Kenpaullone has been used:
  • as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines
  • as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice
  • as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

Azioni biochim/fisiol

Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.

Caratteristiche e vantaggi

This compound is featured on the CDKs and GSK-3 pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Store under argon

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
076M4708V
072K4607

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Ken-ichiro Nakajima et al.
Nature communications, 7, 10268-10268 (2016-01-09)
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