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P3076

Sigma-Aldrich

Platelet-Derived Growth Factor-AA human

PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

PDGF−AA

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About This Item

Numero MDL:
MFCD00081862
Codice UNSPSC:
12352202
NACRES:
NA.77

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥98% (SDS-PAGE and HPLC)

Forma fisica

lyophilized powder

Potenza

1.0-3.0 ng/mL ED50

Qualità

endotoxin tested

PM

28.5 kDa (containing 250 amino acid residues)

Confezionamento

pkg of 10 μg
pkg of 50 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

tecniche

cell culture | mammalian: suitable

Impurezze

<1 EU/μg

N° accesso UniProt

P04085

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... PDGFRA(5154)

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Categorie correlate

Descrizione generale

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

Azioni biochim/fisiol

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

Altre note

Homodimer of the A chain of human PDGF.

Stato fisico

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

Risultati analitici

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Articoli

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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