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Merck
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Documenti fondamentali

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N5504

Sigma-Aldrich

Naphazoline hydrochloride

Sinonimo/i:

2-(1-Naphthylmethyl)imidazoline hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C14H14N2 · HCl
Numero CAS:
550-99-2
Peso molecolare:
246.74
Numero CE:
208-989-2
Numero MDL:
MFCD00012554
Codice UNSPSC:
12352200
ID PubChem:
24278592
NACRES:
NA.77

Stato

powder

Livello qualitativo

100

Ideatore

Allergan

Stringa SMILE

Cl.C1CN=C(Cc2cccc3ccccc23)N1

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
DJDFFEBSKJCGHC-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Azioni biochim/fisiol

Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.
α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.

Caratteristiche e vantaggi

This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCG7846
BCCD1190
BCBZ3486
BCBT1941
BCBS6330V

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Sigma-Aldrich

A9165

N-acetil-L-cisteina

DL-Ditiotreitolo ≥98% (HPLC), ≥99.0% (titration)

Sigma-Aldrich

D0632

DL-Ditiotreitolo

Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Marie Granier et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 56(2), 102-108 (2009-02-28)
Septorhinoplasty is a traumatic procedure that is associated with epistaxis and postoperative pain. The primary objective of this randomized double-blind controlled trial was to determine whether intranasal 5% lidocaine plus naphazoline decreases postoperative pain and lessens the use of rescue
M Gelardi et al.
Journal of biological regulators and homeostatic agents, 23(2), 79-84 (2009-07-11)
A wide variety of nasal irrigation systems are currently available for improving nasal symptoms, but few studies have compared their effectiveness with respect to patient age and type of nasal disease. This pilot study aims to compare the efficacy of
Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Arzu Karakurt et al.
European journal of medicinal chemistry, 57, 275-282 (2012-10-23)
Twenty-three new oxime ester derivatives of nafimidone were synthesized with the prospect of potential anticonvulsant activities. MES and ScM tests were employed for their anticonvulsant activities and rotorod test for neurological deficits. Eighteen compounds were found to be protective against
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