M4145

Minoxidil

≥99% (TLC), powder, androgenetic alopecia drug

• Sinonimo/i: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
• Formula empirica (notazione di Hill): C₉H₁₅N₅O
• Numero CAS: 38304-91-5
• Peso molecolare: 209.25
• Numero CE: 253-874-2
• Numero MDL: MFCD00063409
• Codice UNSPSC: 12352200
• ID PubChem: 24277853
• NACRES: NA.77

Proprietà

• product name: Minoxidil, ≥99% (TLC)
• Saggio: ≥99% (TLC)
• Punto di fusione: 272-274 °C (dec.) (lit.)
• Ideatore: Johnson & Johnson
• Stringa SMILE: NC1=CC(=NC(=N)N1O)N2CCCCC2
• InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2; ZIMGGGWCDYVHOY-UHFFFAOYSA-N
• Informazioni sul gene: human ... KCNJ1(3758)

Descrizione

Applicazioni

Minoxidil has been used as test drug:

• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Azioni biochim/fisiol

Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Activates ATP-activated K⁺ channels; vasodilator; slow or stop hair loss and promote hair regrowth.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319,H335
• Consigli di prudenza: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves