Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

N5266

Sigma-Aldrich

Neurotensin Fragment 8-13 acetate salt

≥97% (HPLC), suitable for ligand binding assays

Sinonimo/i:

L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Formula empirica (notazione di Hill):
C38H64N12O8
Numero CAS:
Peso molecolare:
816.99
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.26

product name

Neurotensin Fragment 8-13 acetate salt, ≥97% (HPLC)

Saggio

≥97% (HPLC)

Forma fisica

powder

tecniche

ligand binding assay: suitable

Colore

white

applicazioni

cell analysis

Temperatura di conservazione

−20°C

Stringa SMILE

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)
DQDBCHHEIKQPJD-UHFFFAOYSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Amino Acid Sequence

Arg-Arg-Pro-Tyr-Ile-Leu

Azioni biochim/fisiol

Neurotensin Fragment 8-13 acetate salt is the smallest active fragment of neurotensin.

Linkage

Smallest active fragment of neurotensin

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

M Kyle Hadden et al.
Neuropharmacology, 49(8), 1149-1159 (2005-08-13)
Neurotensin (NT) and its active fragment NT(8-13) elicit behavioral responses typical of clinically used antipsychotic drugs when administered directly to the brain. However, limited peptide stability and oral bioavailability have prevented these compounds from being developed as relevant pharmaceuticals. Recently
Kevin S Orwig et al.
Journal of medicinal chemistry, 52(7), 1803-1813 (2009-03-18)
Neurotensin(8-13) and two related analogues were used as model systems to directly compare various N-terminal peptide modifications representing both commonly used and novel capping groups. Each N-terminal modification prevented aminopeptidase cleavage but surprisingly differed in its ability to inhibit cleavage
Takaaki Yanai et al.
Bioscience, biotechnology, and biochemistry, 67(2), 380-382 (2003-05-06)
Two peptides that inhibit prolyl endopeptidase were isolated from a red wine made from Cabernet Sauvignon grapes. Their amino acid sequences and IC50 values were Val-Glu-Ile-Pro-Glu (17.0 microM) and Tyr-Pro-Ile-Pro-Phe (87.8 microM). The peptides also suppressed the degradation levels of
Veronique Maes et al.
Journal of medicinal chemistry, 49(5), 1833-1836 (2006-03-03)
Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma. To improve the pharmacokinetic properties, (N(alpha)His)Ac-Arg-NMeArg-Pro-Tyr-Tle-Leu (NT-XII), which is metabolically stabilized at two positions, was further modified. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic
Rodrigo Teodoro et al.
Nuclear medicine and biology, 38(1), 113-120 (2011-01-12)
Several strategies on the development of radiopharmaceuticals have been employed. Bifunctional chelators seem to be a promising approach since high radiochemical yields as well as good in vitro and in vivo stability have been achieved. To date, neurotensin analogs have

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.