N1537
NU7026
≥98% (HPLC), solid
Sinonimo/i:
2-(Morpholin-4-yl)-benzo[h]chromen-4-one
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About This Item
Formula empirica (notazione di Hill):
C17H15NO3
Numero CAS:
Peso molecolare:
281.31
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Colore
tan
Solubilità
DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Stringa SMILE
O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
InChI
1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
KKTZALUTXUZPSN-UHFFFAOYSA-N
Applicazioni
NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).
Azioni biochim/fisiol
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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