MAK112

Arginase Activity Assay Kit

sufficient for 200 colorimetric tests

• Sinonimo/i: Arginase Test Kit
• Codice UNSPSC: 12161503
• NACRES: NA.84

Proprietà

• impiego: sufficient for 200 colorimetric tests
• Metodo di rivelazione: colorimetric
• Malattie correlate: cancer; immunological diseases; gastrointestinal diseases
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... ARG1(383) , ARG2(384) ; mouse ... ARG1(11846) , ARG2(11847) ; rat ... ARG2(29215) , Arg1(29221)

Descrizione

Descrizione generale

Arginase is a manganese-containing enzyme that catalyzes the conversion of arginine to urea and ornithine. Two isoforms of arginase are present in most mammals which differ in their tissue distribution and subcellular localization. Arginase I is a cytoplasmic protein predominantly expressed in the liver where it catalyzes the fifth and final step of the Urea Cycle. Arginase II is a mitochondrial protein with broader tissue distribution whose function may include nitric oxide and polyamine metabolism. Decreased activity or expression of Arginase I results in the autosomal recessive disorder hyperarginemia. Increased serum Arginase activity is implicated in hepatic injury and in certain pathological conditions such as cancer. Arginase also participates in multiple inflammatory reactions in the immune system, such as macrophage-mediated cytotoxicity.

Applicazioni

Arginase Activity Assay Kit has been used to assess the activity of arginase.

Caratteristiche e vantaggi

Compatible with high-throughput handling systems.

Compatibilità

Suitable for the detection of arginase activity in enzyme preparations, serum, plasma, tissue culture, and similar samples. Suitable for studying the effects of drugs on arginase activity.

Principio

In this assay, arginase catalyzes the conversion of arginine to urea and ornithine. The urea produced specifically reacts with the substrate to generate a colored product, proportional to the arginase activity present.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H290,H314,H360FD,H412
• Consigli di prudenza: P202 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A
• Codice della classe di stoccaggio: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable