M9434
Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat
clone 14, tissue culture supernatant
Sinonimo/i:
Anti-MBP
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About This Item
Prodotti consigliati
Origine biologica
rat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
tissue culture supernatant
Tipo di anticorpo
primary antibodies
Clone
14, monoclonal
contiene
0.09% sodium azide
Reattività contro le specie
horse, chicken, human
tecniche
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
Isotipo
IgG
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... MBP(4155)
Descrizione generale
Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.
Specificità
Recognizes amino acids 36-50 of myelin basic protein.
Immunogeno
bovine myelin basic protein.
Azioni biochim/fisiol
Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.
Nota sulla preparazione
Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
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Alexey Belogurov et al.
The Journal of biological chemistry, 289(25), 17758-17766 (2014-04-18)
The vast majority of cellular proteins are degraded by the 26S proteasome after their ubiquitination. Here, we report that the major component of the myelin multilayered membrane sheath, myelin basic protein (MBP), is hydrolyzed by the 26S proteasome in a
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