309795

DIDS disodium salt

≥85% (HPLC), solid, anion transport inhibitor, Calbiochem^®

• Sinonimo/i: DIDS, Disodium Salt, 4,4ʹ-Diisothiocyanostilbene-2,2ʹ-disulfonic Acid, 2Na
• Formula empirica (notazione di Hill): C₁₆H₈N₂O₆S₄ · 2Na
• Numero CAS: 53005-05-3
• Peso molecolare: 498.48
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: DIDS, Disodium Salt, Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
• Livello qualitativo: 100
• Saggio: ≥85% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated; protect from light
• Colore: yellow
• Solubilità: water: 0.5%
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+; YSCNMFDFYJUPEF-OWOJBTEDSA-N

Descrizione

Descrizione generale

Binds covalently and irreversibly to the outer surface of human erythrocyte membrane proteins. Inhibits ATP transport into the endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^- uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has antiulcerous activity.

Binds covalently and irreversibly to the outer surface of human erythrocyte membranes. Inhibits ATP transport into endoplasmic reticulum vesicles. Anion transport inhibitor that inhibits Cl^– uptake (IC₅₀ = 150 nM) in neuroblastoma cells. Has anti-ulcerous properties.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Cl- uptake

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 150 nM inhibiting Cl- uptake in neuroblastoma cells

Attenzione

Toxicity: Irritant (B)

Altre note

Bettendorff, L., et al. 1995. Biochem. Biophys. Res. Commun. 207, 375.
Horie, S., et al. 1993. Res. Commun. Chem. Pathol. Pharmacol. 79, 117.
Mayinger, P., and Meyer, D.I. 1993. EMBO J. 12, 659.
Catantchik, Z.I., and Rothstein, A. 1974. J. Membr. Biol.15, 207.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable