D5782
2′,3′-Dideoxycytidine
≥98% (HPLC)
Sinonimo/i:
ddC
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About This Item
Formula empirica (notazione di Hill):
C9H13N3O3
Numero CAS:
Peso molecolare:
211.22
Beilstein:
654956
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.52
Prodotti consigliati
Origine biologica
synthetic (organic)
Saggio
≥98% (HPLC)
Stato
powder
Colore
colorless
Punto di fusione
217-218 °C (lit.)
Solubilità
water: 50 mg/mL, clear, colorless to faintly yellow
Temperatura di conservazione
−20°C
Stringa SMILE
NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](CO)O2
InChI
1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
WREGKURFCTUGRC-POYBYMJQSA-N
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Applicazioni
2′,3′-Dideoxycytidine is used:
- as a DNA chain-terminating nucleotide for DNA sequencing methods based on the Sanger chain-termination method
- as a nucleoside reverse transcriptase inhibitor (NRTI) to study its effects on the development of mechanical allodynia in aging mice
- as a mitochondrial DNA (mtDNA) replication inhibitor to inhibit the activation of cGAS-STING pathway and study its effects on signaling protein-stimulator of interferon genes (STING), cyclic GMP-AMP synthase (cGAS), and phospho-interferon regulator factor 3 (p-IRF3) expression in mouse hippocampal and microglial cells
- as an NRTI inhibitor to study its effects on the drug induced-mitochondrial toxicity in Caenorhabditis elegans
Azioni biochim/fisiol
2′,3′-Dideoxycytidine (ddC), is an ionic compound and a nucleoside analog. It acts as a nucleoside reverse transcriptase inhibitor and exhibits therapeutic effects against human immunodeficiency virus (HIV) infection. 2′,3′-Dideoxycytidine possesses anti-adenovirus activity and inhibits the adenovirus polymerase.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Carc. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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