M9170
Macrophage Colony-Stimulating Factor from mouse
M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinonimo/i:
CSF-1
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About This Item
Numero CAS:
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
eCl@ss:
32190102
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥98% (SDS-PAGE)
Forma fisica
lyophilized powder
Potenza
0.500-3.000 ng/mL ED50
Qualità
endotoxin tested
PM
dimer 18.2 kDa (containing 156 amino acid residues)
Confezionamento
pkg of 10 μg
tecniche
cell culture | mammalian: suitable
Impurezze
≤1.000 EU/μg
Colore
white
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Csf1(12977)
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Categorie correlate
Applicazioni
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
Azioni biochim/fisiol
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by a number of cells, including fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF can stimulate the proliferation of isolated macrophages, augment the production and release of cytokines and other inflammatory modulators from macrophages, enhance macrophage antibody-dependent cell-mediated cytotoxicity, prime and enhance macrophages in their ability to kill tumor cells and other microorganisms, stimulate pinocytosis, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing of a single M-CSF gene and due to variations in glycosylation, the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Human and mouse M-CSF share approximately 80% sequence homology in the conserved N-terminal region of 150 amino acids. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions.
Stato fisico
Lyophilized from a sterile filtered buffered aqueous solution.
Risultati analitici
The proliferative activity is tested by the dose-dependent stimulation of the murine monocytic cell line, M-NFS-60.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
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Journal of dental research, 92(10), 860-867 (2013-08-03)
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Leung R, et al.
Journal of Bone and Mineral Research, 25(5), 1077-1091 (2010)
Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance
Rendina-Ruedy E, et al.
Journal of Bone and Mineral Metabolism, 34(4), 380-394 (2016)
Yan Li et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3192-3199 (2013-08-13)
Engraftment of human CD34⁺ hematopoietic stem/progenitor cells into immunodeficient mice leads to robust reconstitution of human T and B cells but not monocytes and macrophages. To identify the cause underlying the poor monocyte and macrophage reconstitution, we analyzed human myeloid
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