M3071
Moclobemide
≥98% (HPLC), solid
Sinonimo/i:
4-chloro-N-[2-(4-morpholinyl)ethyl]benzamide, Aurorix, Moclamine
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About This Item
Formula empirica (notazione di Hill):
C13H17ClN2O2
Numero CAS:
Peso molecolare:
268.74
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Colore
white
Solubilità
DMSO: >20 mg/mL
Ideatore
Roche
Temperatura di conservazione
room temp
Stringa SMILE
Clc1ccc(cc1)C(=O)NCCN2CCOCC2
InChI
1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
YHXISWVBGDMDLQ-UHFFFAOYSA-N
Azioni biochim/fisiol
Moclobemide acts as a substrate for cytochrome P450 2C19 (CYP2C19). It also behaves as an inhibitor of cytochrome P450 2D6 (CYP2D6), cytochrome P450 1A2 (CYP1A2 and CYP2C19. Moclobemide is also involved in the increased expression of B-cell lymphoma 2 (BcL-2). It also causes neural stem cell (NSC) differentiation into serotoninergic neuron by extracellular‐regulated kinase (ERK) pathway.
Moclobemide is a reversible monoamine oxidase A inhibitor (MAOI); antidepressant. Elimination half-life in humans = 1 -3 hrs; absolute oral bioavailability. Unlike other MAO inhibitors, does not significantly increase blood pressure in humans upon combination with tyramine.
Caratteristiche e vantaggi
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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I clienti hanno visto anche
Anita Rakic Ignjatovic et al.
British journal of clinical pharmacology, 67(2), 199-208 (2008-12-17)
Moclobemide (MCB) undergoes extensive both presystemic and systemic metabolism that can be affected by concomitant drugs. Valproic acid (VPA) and carbamazepine (CBZ) have been found to interact with psychotropic medications of all classes and many other drugs; VPA acts as
Sven Armbrust et al.
Forensic science international, 195(1-3), e1-e3 (2010-01-16)
Intoxication with antidepressants, frequently encountered in pediatric emergency medicine, can often lead to life threatening situations. While hyperthermia, hypertonicity and rigidity are symptoms indicative of a serotonin syndrome triggered by an intoxication with serotonin reuptake inhibitors or monoamine oxidase inhibitors
A M Bielecka et al.
Naunyn-Schmiedeberg's archives of pharmacology, 382(5-6), 409-417 (2010-09-03)
An increasing body of evidence indicates that glial activation and neuroinflammation play an important role in the pathogenesis of psychiatric and neurodegenerative diseases. Activated glial cells secrete various cytokines that influence neurotransmission, hypothalamus-pituitary-adrenal axis activity, neuronal plasticity and neurogenesis. It
Anita Rakic Ignjatovic et al.
Journal of clinical pharmacology, 51(5), 661-671 (2010-05-25)
Because moclobemide pharmacokinetics vary considerably among individuals, monitoring of plasma concentrations lends insight into its pharmacokinetic behavior and enhances its rational use in clinical practice. The aim of this study was to evaluate whether single concentration-time points could adequately predict
F U Lang et al.
Fortschritte der Neurologie-Psychiatrie, 79(9), 531-534 (2011-08-27)
Sleep apnoea is a common disorder presenting with somatic comorbidities and psychiatric symptoms. This case report describes a 43-year-old man with an organic depressive disorder due to obstructive sleep apnoea. Initially, an atypical depressive episode or schizophrenic residual syndrome had
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