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C6506

Sigma-Aldrich

4-Chloro-DL-phenylalanine

greener alternative

Sinonimo/i:

PCP, PCPA

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About This Item

Formula condensata:
ClC6H4CH2CH(NH2)CO2H
Numero CAS:
7424-00-2
Peso molecolare:
199.63
Numero CE:
231-051-9
Numero MDL:
MFCD00002601
Codice UNSPSC:
12352209
ID PubChem:
24278081
NACRES:
NA.32

Stato

solid

Livello qualitativo

100

Punteggio alternativa più verde

old score: 2
new score: 1
Find out more about DOZN™ Scoring

Caratteristiche più verdi

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Punto di fusione

>240 °C (dec.) (lit.)

Categoria alternativa più verde

, Re-engineered

Temperatura di conservazione

room temp

Stringa SMILE

NC(Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
NIGWMJHCCYYCSF-UHFFFAOYSA-N

Informazioni sul gene

human ... TPH1(7166) , TPH2(121278)

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Categorie correlate

Descrizione generale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Applicazioni

4-Chloro-DL-phenylalanine has been used:
  • as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
  • to induce insomnia in rat models
  • used to treat embryos to examine its effect on serotonin
  • for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
  • to feed flies to explore serotonin effect

Azioni biochim/fisiol

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Tryptophan hydroxylase inhibitor.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H317

Classi di pericolo

Acute Tox. 3 Oral - Skin Sens. 1

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
SHBM3004
SHBL0057
SHBK3607
SHBJ7057
SHBJ4632

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Sigma-Aldrich

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Sigma-Aldrich

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Chromatograms

application for HPLC

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