C6506

4-Chloro-DL-phenylalanine

• Sinonimo/i: PCP, PCPA
• Formula condensata: ClC₆H₄CH₂CH(NH₂)CO₂H
• Numero CAS: 7424-00-2
• Peso molecolare: 199.63
• Numero CE: 231-051-9
• Numero MDL: MFCD00002601
• Codice UNSPSC: 12352209
• ID PubChem: 24278081
• NACRES: NA.32

Proprietà

• Forma fisica: solid
• Livello qualitativo: 100
• Punteggio alternativa più verde: old score: 2; new score: 1; Find out more about DOZN™ Scoring
• Caratteristiche più verdi: Less Hazardous Chemical Syntheses; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• Punto di fusione: >240 °C (dec.) (lit.)
• Categoria alternativa più verde: , Re-engineered
• Temperatura di conservazione: room temp
• Stringa SMILE: NC(Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13); NIGWMJHCCYYCSF-UHFFFAOYSA-N
• Informazioni sul gene: human ... TPH1(7166) , TPH2(121278)

Descrizione

Descrizione generale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Applicazioni

4-Chloro-DL-phenylalanine has been used:

• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Azioni biochim/fisiol

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 - H317
• Consigli di prudenza: P280 - P301 + P310 + P330 - P302 + P352
• Classi di pericolo: Acute Tox. 3 Oral - Skin Sens. 1
• Codice della classe di stoccaggio: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges