L6261
Lipopolysaccharides from Salmonella enterica serotype minnesota
purified by phenol extraction
Sinonimo/i:
LPS
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About This Item
Prodotti consigliati
Origine biologica
Salmonella enterica (serotype minnesota)
Livello qualitativo
Forma fisica
lyophilized powder
Purificato mediante
phenol extraction
Impurezze
<3% Protein (Lowry)
Solubilità
water: soluble
Temperatura di conservazione
2-8°C
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Descrizione generale
Lipopolysaccharide (LPS) is the pyrogenic element arising from enterobacteria such as Escherichia coli and Salmonella enterica. It is an amphiphilic component containing polysaccharides and lipoidic material. LPS is present in the outer membrane of the cell wall of almost all Gram-negative bacteria.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Applicazioni
Lipopolysaccharides from Salmonella enterica serotype minnesota has been used:
- as a toll-like receptors (TLR ) agonist to induce tumor necrosis factor (TNF) α production in cereblon and Rabex-5 deficient mice in vivo,
- to study its effect on prostaglandin-E Synthase (PTGES) protein expression in monocyte-derived macrophages
- as a positive control for the maturation of monocyte-derived dendritic cells (MoDCs) to assess secretion of interleukin-10 and interferon (IFN)-γ
- as a supplement in Roswell park memorial institute (RPMI)media for culturing splenic B cells
- as a toll-like receptor 4 ligand to study its effect on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)
Azioni biochim/fisiol
Lipopolysaccharide (LPS) forms a permeability barrier around the cell surface to restrict the entry of toxic molecules such as antibiotics and bile salts. Owing to their external location, this endotoxin also plays a vital role in host-bacterium interactions by regulating host immune response. LPS is a microbe-associated molecular pattern (MAMP) that serves as a potent agonist for toll-like receptor 4 (TLR4)-MD2-CD14 receptor complex.
Altre note
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 2 Oral
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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