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J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Sinonimo/i:

4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

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About This Item

Formula empirica (notazione di Hill):
C16H20N2
Numero CAS:
749886-87-1
Peso molecolare:
240.34
Codice UNSPSC:
51111800
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

protect from light

Colore

off-white to gray-pink

Solubilità

DMSO: >10 mg/mL

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
YMFNPBSZFWXMAD-UHFFFAOYSA-N

Applicazioni

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Azioni biochim/fisiol

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Altre note

Light and air sensitive.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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TPCA-1 ≥95% (HPLC)

Sigma-Aldrich

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SN50 trifluoroacetate salt ≥95% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Ammonium pyrrolidinedithiocarbamate ~99%

Sigma-Aldrich

P8765

Ammonium pyrrolidinedithiocarbamate

Rolipram solid, ≥98% (HPLC)

Sigma-Aldrich

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Rolipram

Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
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HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
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