I2765

Ibotenic acid

~95% (TLC), solid, neurotoxin

• Sinonimo/i: α-Amino-3-hydroxy-5-isoxazoleacetic acid
• Formula empirica (notazione di Hill): C₅H₆N₂O₄
• Numero CAS: 2552-55-8
• Peso molecolare: 158.11
• Numero MDL: MFCD00069294
• Codice UNSPSC: 12352209
• ID PubChem: 24277994
• NACRES: NA.32

Proprietà

• Nome del prodotto: Ibotenic acid, ~95%, solid
• Saggio: ~95%
• Livello qualitativo: 100
• Stato: solid
• Colore: white
• Solubilità: H₂O: 1 mg/mL, clear, colorless (with sonication); 0.1 M NaOH: 10.7 mg/mL; 0.1 M HCl: 4.7 mg/mL
• Stringa SMILE: NC(C(O)=O)C1=CC(=O)NO1
• InChI: 1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10); IRJCBFDCFXCWGO-UHFFFAOYSA-N
• Informazioni sul gene: rat ... Grm1(24414) , Grm2(24415)

Descrizione

Applicazioni

Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.

Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Azioni biochim/fisiol

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P301 + P310 + P330
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges