Q2128

Quisqualic acid

powder

• Sinonimo/i: β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
• Formula empirica (notazione di Hill): C₅H₇N₃O₅
• Numero CAS: 52809-07-1
• Peso molecolare: 189.13
• Beilstein: 1078734
• Numero MDL: MFCD00069337
• Codice UNSPSC: 12352106
• ID PubChem: 24278004
• NACRES: NA.32

Proprietà

• Forma fisica: powder
• Livello qualitativo: 200
• Colore: white to off-white
• Solubilità: ethanol: <0.17 mg/mL; H₂O: 0.5 mg/mL; 0.1 M HCl: 1.4 mg/mL; 1 M NH4OH: 20 mg/mL; organic solvents: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: N[C@@H](CN1OC(=O)NC1=O)C(O)=O
• InChI: 1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1; ASNFTDCKZKHJSW-REOHCLBHSA-N
• Informazioni sul gene: rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418)

Descrizione

Descrizione generale

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Applicazioni

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

Azioni biochim/fisiol

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves