H5002
17α-Hydroxypregnenolone
Sinonimo/i:
3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
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About This Item
Formula empirica (notazione di Hill):
C21H32O3
Numero CAS:
Peso molecolare:
332.48
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Livello qualitativo
Stringa SMILE
C[C@]1(CC[C@H](O)C2)C2=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4(C(C)=O)O
InChI
1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3
JERGUCIJOXJXHF-UHFFFAOYSA-N
Descrizione generale
17α-hydroxypregnenolone is a derived from pregnenolone.
Applicazioni
17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.
Azioni biochim/fisiol
17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Shogo Haraguchi et al.
Endocrinology, 153(2), 794-805 (2011-12-01)
7α-Hydroxypregnenolone (7α-OH PREG) is a newly identified bioactive neurosteroid stimulating locomotor activity in the brain of newt, a wild animal, which serves as an excellent model to investigate the biosynthesis and biological action of neurosteroids. Here, we show that acute
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General and comparative endocrinology, 168(2), 275-279 (2010-02-09)
We now know that steroids can be synthesized de novo by the brain and the peripheral nervous system. Such steroids are called neurosteroids and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. Our studies over the
Kazuyoshi Tsutsui et al.
General and comparative endocrinology, 176(3), 440-447 (2011-12-06)
Seasonally-breeding amphibians have served as excellent animal models to investigate the biosynthesis and biological actions of neurosteroids. Previous studies have demonstrated that the brain of amphibians possesses key steroidogenic enzymes and produces pregnenolone, a precursor of steroid hormones, and other
Tamara S Hannon et al.
Journal of pediatric and adolescent gynecology, 25(1), 82-85 (2011-11-18)
Little is known about racial differences in androgen levels among obese children. The objective of this pilot study was to compare basal and stimulated androgen levels in a cross-sectional sample of obese black and white pubertal females. STUDY DESIGN, SETTING
Teppei Koyama et al.
Annals of the New York Academy of Sciences, 1163, 444-447 (2009-05-22)
We recently identified 7alpha-hydroxypregnenolone as a novel amphibian neurosteroid stimulating locomotor activity in newts. Because male newts show marked diurnal changes in locomotor activity, we hypothesized that 7alpha-hydroxypregnenolone may be a key factor for the induction of diurnal changes in
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