SML1497

Canrenone

≥97% (HPLC)

• Sinonimo/i: (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
• Formula empirica (notazione di Hill): C₂₂H₂₈O₃
• Numero CAS: 976-71-6
• Peso molecolare: 340.46
• Numero MDL: MFCD00071735
• Codice UNSPSC: 12352200
• ID PubChem: 329825921
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Forma fisica: powder
• Attività ottica: [α]/D +17 to +24°, c = 1 in chloroform-d
• Colore: white to beige
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
• InChI: 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1; UJVLDDZCTMKXJK-WNHSNXHDSA-N
• Informazioni sul gene: human ... NR3C2(4306)

Descrizione

Azioni biochim/fisiol

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H351,H411
• Consigli di prudenza: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classi di pericolo: Aquatic Chronic 2 - Carc. 2 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable