H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

≥98% (HPLC), solid

• Sinonimo/i: (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
• Formula empirica (notazione di Hill): C₁₆H₂₅NO · HBr
• Numero CAS: 78095-19-9
• Peso molecolare: 328.29
• Numero MDL: MFCD00153810
• Codice UNSPSC: 12352200
• ID PubChem: 24278480
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Attività ottica: [α]25/D +68.2°, c = 1 in methanol(lit.)
• Condizioni di stoccaggio: desiccated; protect from light
• Colore: white to off-white
• Solubilità: H₂O: >10 mg/mL at ±60 °C (with sonication)
• Stringa SMILE: Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
• InChI: 1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1; BATPBOZTBNNDLN-PFEQFJNWSA-N
• Informazioni sul gene: human ... HTR1A(3350)

Descrizione

Applicazioni

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:

• in mice to test the activity of the serotonin receptor
• to test its effect on zebrafish melanocyte migration and survival
• to stimulate hippocampal neurons

Azioni biochim/fisiol

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT_1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)