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Merck
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Key Documents

G7048

Sigma-Aldrich

Proguanil hydrochloride

≥95% (HPLC)

Sinonimo/i:

Chlorguanide, N1-(4-Chlorophenyl)-N5-isopropylbiguanide

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About This Item

Formula empirica (notazione di Hill):
C11H16ClN5·HCl
Numero CAS:
Peso molecolare:
290.19
Numero CE:
Numero MDL:
Codice UNSPSC:
51101906
ID PubChem:
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Solubilità

acetonitrile: water: ~1 mg/mL (60/40)

Ideatore

AstraZeneca

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1

InChI

1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
SARMGXPVOFNNNG-UHFFFAOYSA-N

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Applicazioni

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

Azioni biochim/fisiol

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Caratteristiche e vantaggi

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbones

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Clinical pharmacology and therapeutics, 91(4), 718-725 (2012-03-09)
In this investigation we evaluate the relevance of a model-based approach for pharmacokinetic (PK) bridging and dose selection of drug combinations in children. The fixed-dose combination of atovaquone (ATV) and proguanil (PGN) was used for illustration purposes. A population PK
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