G5044

GR 32191B

≥98% (HPLC), solid

• Sinonimo/i: (4Z)-7-[(1R,2R,3S,5S)-5-([1,1′-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride
• Formula empirica (notazione di Hill): C₃₀H₄₀NO₄Cl
• Numero CAS: 87248-13-3
• Peso molecolare: 514.10
• Numero MDL: MFCD04113055
• Codice UNSPSC: 12352200
• ID PubChem: 329799744
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: off-white
• Punto di fusione: 127-128 °C
• Solubilità: H₂O: ~16 mg/mL
• Ideatore: GlaxoSmithKline
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.O[C@H]1C[C@H](OCc2ccc(cc2)-c3ccccc3)[C@H](CC\C=C/CCC(O)=O)[C@H]1N4CCCCC4
• InChI: 1S/C30H39NO4.ClH/c32-27-21-28(35-22-23-15-17-25(18-16-23)24-11-5-3-6-12-24)26(13-7-1-2-8-14-29(33)34)30(27)31-19-9-4-10-20-31;/h1-3,5-6,11-12,15-18,26-28,30,32H,4,7-10,13-14,19-22H2,(H,33,34);1H/b2-1-;/t26-,27-,28-,30+;/m0./s1; ZYOBZRTZRQKKNC-UGNABIHOSA-N

Descrizione

Azioni biochim/fisiol

Selective TP prostanoid receptor antagonist. Inhibits U-46619-induced contraction of guinea pig trachea with IC₅₀=1.8 nM.

Caratteristiche e vantaggi

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Manufactured and sold under agreement from Glaxo­Smith­Kline

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)