Passa al contenuto
Merck
Tutte le immagini(2)

Key Documents

C9301

Sigma-Aldrich

Chicken Collagen Type II

from chicken sternal cartilage, powder, suitable for cell culture

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Numero CAS:
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
NACRES:
NA.75

product name

Collagen from chicken sternal cartilage, Type II (Miller), powder, BioReagent, suitable for cell culture

Origine biologica

chicken (Sternal cartilage)

Livello qualitativo

Tipo

Type II (Miller)

Nome Commerciale

BioReagent

Forma fisica

powder

Confezionamento

glass bottle of 100 mg
poly bottle of 25 mg
glass bottle of 5 mg

Concentrazione

60-80% (biuret)

tecniche

cell culture | mammalian: suitable

Copertura della superficie

6‑10 μg/cm2

Solubilità

acetic acid: 0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)

N° accesso UniProt

Specificità del legame

Peptide Source: Fibrinogen

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Informazioni sul gene

chicken ... COL2A1(395069)

Descrizione generale

Collagen is made of three polypeptide chains. Type 2 collagen is ubiquitously present in the hyaline cartilage. It is a homotrimer made of three α1 chains. Type 2 collagen is also predominant in nucleus pulposus of the vertebral disc and vitreous body of the eye. The proteoglycan obtained from the chicken sternal cartilage is similar to type nine collagen structure.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Applicazioni

Collagen from chicken sternal cartilage has been used:

  • in enzyme–linked immunosorbent assay (ELISA).
  • chondrocyte-mediated tissue production in vitro.
  • induction, treatment, and assessment of collagenα induced arthritis (CIA).
  • cell proliferation assay.
  • as a coating for cell culture surfaces.

Azioni biochim/fisiol

Collagen breaks down metabolically in the body to release N-telopeptide, which is the N-terminus of collagen. There is also C-telopeptide, which is presumably the C-terminus. N-telopeptide is released in urine, and its detection in diagnostic tests is used to screen for osteoporosis.

Caratteristiche e vantaggi

This collagen has been tested in culture with mammalian cells to verify it is low in endotoxin content.

Altre note

Major component of articular cartilage.

Nota sulla preparazione

Prepared by a modification of the method of Trentham, D.E., et al.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

Lipopolysaccharide Increases the Incidence of Collagen?Induced Arthritis in Mice Through Induction of Protease HTRA?1 Expression.
Hou Y, et al.
Arthritis and Rheumatism, 65(11), 2835-2846 (2013)
Clinical Impact of Bone and Connective Tissue Markers (2012)
Blockade of the interleukin?7 receptor inhibits collagen?induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.
Hartgring S A, et al.
Arthritis and Rheumatism, 62(9), 2716-2725 (2010)
Deletion of either CD55 or CD97 ameliorates arthritis in mouse models.
Hoek R M, et al.
Arthritis and Rheumatism, 62(4), 1036-1042 (2010)
High-density lipoproteins attenuate high glucose-impaired endothelial cell signaling and functions: potential implications for improved vascular repair in diabetes.
Chen X, et al.
Cardiovascular Diabetology, 16(1), 121-121 (2017)

Articoli

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.