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C5851

CGP 35348 hydrate

Name: CGP 35348 hydrate
Brand: SIGMA

≥97% (NMR), solid

Sinonimo/i:

(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

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About This Item

Formula empirica (notazione di Hill):

C₈H₂₀NO₄P · xH₂O

Numero CAS:

123690-79-9

Peso molecolare:

225.22 (anhydrous basis)

Numero MDL:

MFCD11045877

Codice UNSPSC:

12352200

ID PubChem:

329775103

NACRES:

NA.77

Saggio

≥97% (NMR)

Forma fisica

solid

Condizioni di stoccaggio

desiccated

Colore

white

Solubilità

H₂O: >20 mg/mL

Ideatore

Novartis

Temperatura di conservazione

−20°C

Stringa SMILE

O.CCOC(OCC)P(O)(=O)CCCN

InChI

1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2
SRBHGEXMDCJOMS-UHFFFAOYSA-N

Applicazioni

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

to study its effects on intrinsic optical signal (IOS) in rat hippocampus
alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
to study its effects on hepatocellular carcinoma cells (HCC)

Azioni biochim/fisiol

CGP 35348 is a γ-aminobutyric acid-B (GABA_B) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Avvertenza

Product is hygroscopic

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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GABAB receptor antagonists: from synthesis to therapeutic applications.

H Bittiger et al.

Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)

Infantile spasms and Down syndrome: a new animal model.

Miguel A Cortez et al.

Pediatric research, 65(5), 499-503 (2009-02-05)

Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hypothesis that

Pharmacological and autoradiographic studies on the pathophysiological role of GABA(B) receptors in the dystonic hamster: pronounced antidystonic effects of baclofen after striatal injections.

S E Sander et al.

Neuroscience, 162(2), 423-430 (2009-05-12)

The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles. The underlying mechanisms of this movement disorder are still unclear. Previous

GABA-B receptor antagonist CGP 35348 interferes with an arrest of cortical epileptic afterdischarges in developing rats.

Pavel Mareš

Epilepsy research, 92(2-3), 125-133 (2010-09-25)

Epileptic seizures activate not only excitatory but also inhibitory systems what results in an arrest of seizures. Our recent data indicate that GABAergic inhibition plays an important role in this process in cortically elicited seizures. We started to study the

Short-term synaptic plasticity at the main and vomeronasal olfactory receptor to mitral cell synapse in frog.

K R Delaney et al.

The European journal of neuroscience, 30(11), 2077-2088 (2010-02-05)

Synaptic responses resulting from stimulation of the main olfactory and vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) of frog, Rana pipiens, to test the hypothesis that properties of these synapses would reflect the distinct differences

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