05-23-0050

Corticotropin Releasing Factor, Human and Rat

An immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla.

• Sinonimo/i: Corticotropin Releasing Factor, Human and Rat, CRF, CRH, Corticotropin-releasing hormone
• Formula empirica (notazione di Hill): C₂₀₈H₃₄₄N₆₀O₆₃S₂
• Numero CAS: 86784-80-7
• Peso molecolare: 4757.45
• Numero MDL: MFCD00213806
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Forma fisica: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• tecniche: cell based assay: suitable
• Colore: white to off-white
• Solubilità: 5% NH₄OH: 1 mg/mL (prepared with H₂O)
• N° accesso UniProt: P01143; P06850
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• Informazioni sul gene: human ... CRH(1392)

Descrizione

Descrizione generale

Research area: Neuroscience

Corticotropin-releasing factor (CRF), a 41-amino-acid peptide, is widely expressed in neurons throughout the mammalian brain and several peripheral tissues such as the pancreas, stomach, and small intestine. It functions by stimulating the secretion of corticotropin in the anterior pituitary, which in turn regulates adrenal cortex synthetic/secretory activity. Human CRF is located on chromosome 8q13 and is identical to rat and mouse CRF. It assumes a random coil structure under physiological conditions and α-helix shape in an amphiphilic environment.

Applicazioni

Corticotropin-releasing factor (CRF) has been used to investigate its effects on Cerebellar Motor Control and Ataxia in rats.

Azioni biochim/fisiol

Cell permeable: no

Primary Target: An immunomodulatory neuropeptide

The product does not compete with ATP.

Reversible: no

Corticotropin-releasing factor (CRF), a neuropeptide also known as corticotropin-releasing factor (CRH), plays a crucial role in the stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis and extrahypothalamic pathways. It acts by releasing Adrenocorticotropic Hormone (ACTH) from the anterior pituitary, stimulating the sympathetic nervous system and adrenal medulla. Besides its involvement in stress regulation, CRF peptides have diverse effects on both, the central nervous system and peripheral tissues. This includes potential regulation of anxiety, mood, feeding, inflammation, gastric emptying, and blood pressure. Aberrant secretion of CRF could potentially contribute to the development of various neuropsychiatric disorders such as anxiety, depression, obsessive-compulsive disorder, Parkinson′s disease, Alzheimer′s disease, alcohol withdrawal, and post traumatic stress disorder. Also, CRF and CRF-R1 (Corticotropin-Releasing Factor Receptor 1) have been observed in lymphoid organs and sites of inflammation, suggesting a role in immune system regulation.

Confezionamento

Yes

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH₂

Stato fisico

Supplied as an acetate salt.

Ricostituzione

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Barmack, N.H., and Errico, P. 1993. J. Neurosci. 13, 4647.
Wei, E.T., et al. 1993. Ciba Found. Symp. 172, 258.
Smith, E.M., et al. 1986. Nature321, 881.
Udelsman, R., et al. 1986. Nature319, 147.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable