B4186

Butyrylcholinesterase human

vial of ≥4 units

• Sinonimo/i: Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
• Numero CAS: 9001-08-5
• Classificazione EC (Enzyme Commission): 3.1.1.8 (BRENDA, IUBMB)
• Numero CE: 232-579-2
• Numero MDL: MFCD00081455
• Codice UNSPSC: 12352204
• NACRES: NA.54

Proprietà

• Forma fisica: powder
• Livello qualitativo: 200
• Attività specifica: ≥50 units/mg protein
• Confezionamento: vial of ≥4 units
• N° accesso UniProt: P06276
• Temperatura di conservazione: 2-8°C
• Informazioni sul gene: human ... BCHE(590)

Descrizione

Applicazioni

BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .

Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.

Azioni biochim/fisiol

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates. BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.

Definizione di unità

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

Risultati analitici

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H334
• Consigli di prudenza: P261 - P284 - P501
• Classi di pericolo: Resp. Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable