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Key Documents

A8301

Sigma-Aldrich

Albumin, glycated human

lyophilized powder

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About This Item

Numero CAS:
Numero MDL:
Codice UNSPSC:
12352202
NACRES:
NA.25

Origine biologica

human

Livello qualitativo

Saggio

90-100% protein basis (biuret)

Forma fisica

lyophilized powder

Grado di funzionalizzazione

1-5 mol hexose (as fructosamine) per mol albumin

tecniche

cell culture | mammalian: suitable

N° accesso UniProt

Temperatura di conservazione

−20°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
QYSGYZVSCZSLHT-UHFFFAOYSA-N

Informazioni sul gene

human ... ALB(213)

Descrizione generale

Albumin gene is mapped to human chromosome 4q13.3. It is synthesized as a preproalbumin with 609 amino acids in the liver. The mature albumin comprising 585 residues, is generated by the cleavage of signal peptide. Albumin is the major circulating protein in serum. It comprises three domains (I, II and III), each of which is subdivided into two subdomains A and B. A total of six ligand binding site is associated with albumin. Domain IIA and IIIA harbor small heterocyclic or aromatic compounds binding site. Long-chain fatty acid binding sites is present in IB and IIIB domains.

Applicazioni

Albumin, glycated human has been used:
  • as a component of serum-free medium for retinal microglia activation
  • to stimulate immortalised proximal tubule epithelial (HK-2) cells for fibronectin production
  • as medium supplement in human retinal microvascular endothelial cells (HRMECs) cultures to test its effect on family with sequence similarity 18, member B (FAM18B) expression


Naturally occurring glycated albumin is a sensitive indicator of glycemic control by diabetic patients.

Azioni biochim/fisiol

Albumin is crucial for physiological processes and is the major transporter for lipids, metal ions and amino acids. It has antioxidant functionality and binds to drugs as well. Mutation in the albumin gene is implicated in an autosomal recessive disorder called Analbuminemia, which is characterized by low levels of albumin. The major glycation site is lysine 525 in albumin. Glycated albumin is a marker of glycemia in diabetes mellitus patients and is useful in assessment of HbA1c based glycemic control.

Stato fisico

Lyophilized powder containing citrate buffer salts

Nota sulla preparazione

Glycated in vitro

Altre note

View more information on human serum albumin.

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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