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A4393

Sigma-Aldrich

R-(−)-Apomorphine hydrochloride hemihydrate

calcined, ≥98% (with NaOH, titration)

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About This Item

Formula condensata:
C17H17NO2 · HCl · 1/2H2O
Numero CAS:
41372-20-7
Peso molecolare:
312.79
Numero CE:
206-243-0
Numero MDL:
MFCD00150904
Codice UNSPSC:
12352210
ID PubChem:
24278821
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥98% (with NaOH, titration)

Stato

calcined
 (Powder to Crystalline Powder)

Condizioni di stoccaggio

protect from light
under inert gas

Colore

white to gray

Punto di fusione

285-287 °C (lit.)

Solubilità

H2O: ~10 mg/mL, clear, yellow-green

Stringa SMILE

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1
CXWQXGNFZLHLHQ-DPFCLETOSA-N

Informazioni sul gene

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Applicazioni

R-(-)-Apomorphine hydrochloride hemihydrate has been used as a dopamine receptor agonist to study its effects of rotational behavior in rat models of Parkinson′s disease.

Azioni biochim/fisiol

R-(−)-Apomorphine acts as a non-selective D1 and D2 dopamine receptor agonist. It shows therapeutic effects against Parkinson′s disease and male erectile dysfunction. R-(−)-Apomorphine also shows neuroprotective, radical scavenging, and emetic effects. Apomorphine stimulates the brain chemoreceptor trigger zone. It stimulates the chemoreceptor trigger zone in the brain.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
SLCB4167
SLBP2436V
SLBP2431V
SLBF5500V
SLBF6369V

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Sigma-Aldrich

SMB00377

Magnoflorine

(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC)

Sigma-Aldrich

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Qian Li et al.
Neuron, 76(5), 1030-1041 (2012-12-12)
Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN)
Kristina Malinovskaja et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 83(3), 477-484 (2012-12-05)
The objective of this study was to test a drug delivery system that combines iontophoresis and cation-exchange fibers as drug matrices for the controlled transdermal delivery of antiparkinsonian drug apomorphine. Positively charged apomorphine was bound to the ion-exchange groups of
Fumitoshi Kodaka et al.
European journal of nuclear medicine and molecular imaging, 40(4), 574-579 (2012-12-15)
Dopamine D receptors (DRs) have two affinity states for endogenous dopamine, referred to as high-affinity state (D ), which has a high affinity for endogenous dopamine, and low-affinity state (D ). The density of D can be measured with (R)-2-CHO-N-n-propylnorapomorphine
Yanpeng Yuan et al.
Theranostics, 8(17), 4679-4694 (2018-10-04)
Autologous neural stem cells (NSCs) may offer a promising source for deriving dopaminergic (DA) cells for treatment of Parkinson's disease (PD). Methods: By using Sendai virus, human peripheral blood mononuclear cells (PBMNCs) were reprogrammed to induced NSCs (iNSCs), which were
Anthony C Vernon et al.
Methods in molecular biology (Clifton, N.J.), 711, 487-510 (2011-02-01)
Neurotoxin-based rodent models of Parkinson's disease (PD) are widely used for pre-clinical evaluation of novel therapeutics for PD and have provided insights into mechanisms underlying motor dysfunction and nigrostriatal degeneration in PD. Predominantly, magnetic resonance imaging (MRI) studies in such
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