SMB00377

Magnoflorine

≥98% (HPLC)

• Sinonimo/i: (6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol
• Formula empirica (notazione di Hill): C₂₀H₂₄NO₄
• Numero CAS: 2141-09-5
• Peso molecolare: 342.41
• Numero MDL: MFCD09031380
• Codice UNSPSC: 12352205
• ID PubChem: 329824978
• NACRES: NA.25

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• applicazioni: metabolomics; vitamins, nutraceuticals, and natural products
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32
• InChI: 1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1; YLRXAIKMLINXQY-ZDUSSCGKSA-O

Descrizione

Descrizione generale

Magnoflorine is a secondary metabolite and an alkaloid with a quaternary aporphine configuration. It can be found in roots, rhizomes, stems, barks, or seeds of many herbal plants such as Caulophyllum thalictroides (blue cohosh), Arisolochai bracteate, P. amurense, S. acutum, Tinospora crispa, Coptidis rhizome, etc. Magnoflorine constitutes approximately 65 % of the total alkaloids in roots and rhizomes of blue cohosh. It is also known as thalictrine and escholine.

Applicazioni

Magnoflorin has been used to test its contractile effects on isolated mouse uterine smooth muscle tissues and on isolated strips of Mus musculus distal colon smooth muscle tissues.

Azioni biochim/fisiol

Magnoflorine possesses several biochemical and pharmacological properties such as antioxidant, anti-inflammatory, immunomodulatory, anti-diabetic, anti-fungal, cardiovascular protective, and neuropsychological. It also acts as an α-tyrosinase inhibitor. It helps to increase pro-inflammatory responses induced by lipopolysaccharide (LPS). It exerts antitumor, anti-cancer activities by inhibiting gastric cancer progression gastric cancer cell xenograft mouse model.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332
• Consigli di prudenza: P261 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable