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A2251

Sigma-Aldrich

Acetyl-β-methylcholine chloride

≥98% (TLC), powder

Sinonimo/i:

(2-Acetoxypropyl)trimethylammonium chloride, Methacholine chloride

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About This Item

Formula condensata:
CH3COOCH(CH3)CH2N(Cl)(CH3)3
Numero CAS:
62-51-1
Peso molecolare:
195.69
Beilstein:
4162373
Numero CE:
200-537-2
Numero MDL:
MFCD00011817
Codice UNSPSC:
12352211
ID PubChem:
24277821
NACRES:
NA.25

Saggio

≥98% (TLC)

Stato

powder

Punto di fusione

171-173 °C (lit.)

Solubilità

H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.)

Temperatura di conservazione

−20°C

Stringa SMILE

[Cl-].CC(C[N+](C)(C)C)OC(C)=O

InChI

1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
JHPHVAVFUYTVCL-UHFFFAOYSA-M

Informazioni sul gene

human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

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Categorie correlate

Applicazioni

Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.

Azioni biochim/fisiol

Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ3788
MKCQ3945
MKCP6579
MKCM4969
MKCN6991

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Carbachol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1511

Carbachol

Albumina lyophilized powder, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

A5503

Albumina

Carbamoylcholine chloride ≥98% (titration), crystalline

Sigma-Aldrich

C4382

Carbamoylcholine chloride

Cloruro di acetilcolina suitable for cell culture

Sigma-Aldrich

A2661

Cloruro di acetilcolina

Terbutaline hemisulfate salt

Sigma-Aldrich

T2528

Terbutaline hemisulfate salt

Physostigmine salicylate European Pharmacopoeia (EP) Reference Standard

P1600000

Physostigmine salicylate

J G Martin et al.
Canadian journal of physiology and pharmacology, 70(4), 597-601 (1992-04-01)
Airway responsiveness to methacholine and other bronchoconstrictors is highly variable within and among species. The aim of the experiments in this report was to evaluate the importance of the quantity of airway smooth muscle as a determinant of intra- and
Bing Han et al.
PloS one, 6(2), e17236-e17236 (2011-03-02)
The great advances of nanomaterials have brought out broad important applications, but their possible nanotoxicity and risks have not been fully understood. It is confirmed that exposure of environmental particulate matter (PM), especially ultrafine PM, are responsible for many lung
Mina Youssef et al.
The Journal of pharmacology and experimental therapeutics, 373(3), 476-487 (2020-04-11)
Zona pellucida binding protein 2 (Zpbp2) and ORMDL sphingolipid biosynthesis regulator 3 (Ormdl3), mapped downstream of Zpbp2, were identified as two genes associated with airway hyper-responsiveness (AHR). Ormdl3 gene product has been shown to regulate the biosynthesis of ceramides. Allergic
Rifat A Chaudry et al.
Thorax, 69(6), 580-585 (2014-02-14)
Asthma and airway hyper-responsiveness are reportedly more common in children with sickle cell disease (SCD). To determine airway responsiveness, airway inflammation and clinical features of asthma in SCD. A prospective, single-centre study of 50 SCD children without overt pulmonary vascular
Mark J Hoegger et al.
Science (New York, N.Y.), 345(6198), 818-822 (2014-08-16)
Lung disease in people with cystic fibrosis (CF) is initiated by defective host defense that predisposes airways to bacterial infection. Advanced CF is characterized by a deficit in mucociliary transport (MCT), a process that traps and propels bacteria out of
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