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14370

Sigma-Aldrich

Bilirubina

purum, ≥95.0% (UV)

Sinonimo/i:

Bile pigment, Hemetoidin

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About This Item

Formula empirica (notazione di Hill):
C33H36N4O6
Numero CAS:
635-65-4
Peso molecolare:
584.66
Beilstein:
74376
Numero CE:
211-239-7
Numero MDL:
MFCD00005499
Codice UNSPSC:
12352202
ID PubChem:
57647150
NACRES:
NA.25

Grado

purum

Livello qualitativo

100

Saggio

≥95.0% (UV)

Forma fisica

powder

Residuo alla calcinazione

≤0.5%

Stringa SMILE

CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
BPYKTIZUTYGOLE-IFADSCNNSA-N

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Categorie correlate

Descrizione generale

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.

Applicazioni

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.

Azioni biochim/fisiol

Più del 99% della bilirubina totale è trasportata coniugata con albumina. Livelli di bilirubina più alti del normale possono condurre a gravi danni neurologici mentre livelli appena più elevati della norma sono collegati a protezione contro lo stress ossidativo.
Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher. This bile pigment has both antioxidant and toxic properties. It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs). It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases. Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease. It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.

Risultati analitici

λmax. ∼453 nm, mol. absorption >56100 (chloroform)

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentially relates
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Recent epidemiological and clinical data show protection from CVD (cardiovascular disease), all-cause mortality and cancer in subjects with GS (Gilbert's syndrome), which is characterized by a mildly elevated blood bilirubin concentration. The established antioxidant effect of bilirubin, however, contributes only
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