2011

Bilirubin

solid, bile pigment, Calbiochem^®

• Sinonimo/i: Bilirubin
• Formula empirica (notazione di Hill): C₃₃H₃₆N₄O₆
• Numero CAS: 635-65-4
• Peso molecolare: 584.66
• Numero MDL: MFCD00005499
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.
• Livello qualitativo: 100
• Descrizione: RTECS - DU3038000; Merck USA index - 14, 1218
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: red-brown
• Solubilità: chloroform: 1 mg/mL; alkaline solution: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 10-30°C
• Stringa SMILE: [nH]1c(c(c(c1\C=C4/NC(=O)C(=C/4C)C=C)C)CCC(=O)O)Cc2[nH]c(c(c2CCC(=O)O)C)\C=C3/NC(=O)C(=C/3C=C)C
• InChI: 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-; BPYKTIZUTYGOLE-IFADSCNNSA-N

Descrizione

Descrizione generale

Bilirubin is an orange-yellow bile pigment and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL. Serum levels of bilirubin in healthy newborns are less than 15 mg/dl. This product corresponds to the unconjugated form.

Azioni biochim/fisiol

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice. Bilirubin levels act as biomarkers in liver and blood disorders. Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant. However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.

Ricostituzione

Unstable in basic solutions; reconstitute just prior to use.

Altre note

Extinction coefficient (454 nm, CHCl₃):59,100-62,300 M^-1cm^-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable