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Y0001177

Desametasone

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

(11β,16α)-9-fluoro-11,17,21-triidrossi-16-metilpregna-1,4-diene-3,20-dione, 9α-fluoro-16α-metil-11β,17α,21-triidrossi-1,4-pregnadiene-3,20-dione, 9α-fluoro-16α-metilprednisolone, Prednisolone F

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About This Item

Formula empirica (notazione di Hill):
C22H29FO5
Numero CAS:
50-02-2
Peso molecolare:
392.46
Beilstein:
2066651
Numero MDL:
MFCD00064136
Codice UNSPSC:
41116107
ID PubChem:
329831293
NACRES:
NA.24

Origine biologica

synthetic

Grado

pharmaceutical primary standard

agenzia

EP

Famiglia di API

dexamethasone

Forma fisica

powder

Confezionamento

pkg of 10 mg

Produttore/marchio commerciale

EDQM

Condizioni di stoccaggio

protect from light

Punto di fusione

262-264 °C (lit.)
262-264 °C

Solubilità

water: <0.1 g/L

applicazioni

pharmaceutical (small molecule)

Formato

neat

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Stringa SMILE

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
UREBDLICKHMUKA-CXSFZGCWSA-N

Informazioni sul gene

human ... NR3C1(2908)

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Categorie correlate

Descrizione generale

Dexamethasone belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Dexamethasone is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.

Azioni biochim/fisiol

Agente antinfiammatorio glucocorticoide. Regola la sopravvivenza, la crescita e la differenziazione delle cellule T. Inibisce l′induzione dell′ossido nitrico sintasi.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360FD

Classi di pericolo

Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Desametasone meets USP testing specifications

Sigma-Aldrich

D9184

Desametasone

Dexamethasone solution 1.0&#160;mg/mL in methanol, ampule of 1&#160;mL, certified reference material, Cerilliant&#174;

Supelco

D-085

Dexamethasone solution

Dexamethasone Sodium Phosphate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1768

Dexamethasone Sodium Phosphate

Desametasone &#8805;98% (HPLC), powder

Sigma-Aldrich

D1756

Desametasone

Desametasone powder, BioReagent, suitable for cell culture, &#8805;97%

Sigma-Aldrich

D4902

Desametasone

S Choi et al.
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Brachial plexus nerve blocks (BPBs) have analgesic and opioid sparing benefits for upper extremity surgery. Single-injection techniques are limited by the pharmacological duration and therapeutic index of local anaesthetics (LAs). Continuous catheter techniques, while effective can present management challenges. Off-label
Sara Bringhen et al.
Blood, 124(1), 63-69 (2014-05-24)
This multicenter, open-label phase 2 trial determined the safety and efficacy of carfilzomib, a novel and irreversible proteasome inhibitor, in combination with cyclophosphamide and dexamethasone (CCyd) in patients with newly diagnosed multiple myeloma (NDMM) ≥65 years of age or who
A Keith Stewart et al.
The New England journal of medicine, 372(2), 142-152 (2014-12-09)
Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. We randomly assigned 792
Wei Zheng et al.
Genes & development, 28(14), 1592-1603 (2014-07-18)
Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern during collecting vessel development, but what regulates this process is
Alexandre Denoyer et al.
Ophthalmology, 122(4), 669-676 (2014-12-03)
To compare small incision lenticule extraction (SMILE) versus LASIK for post-refractive dry eye disease. Prospective, comparative, nonrandomized clinical study. Thirty patients scheduled for bilateral myopic SMILE and 30 age-, sex-, and refraction-matched patients scheduled for bilateral myopic LASIK were enrolled
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Protocolli

Dexamethasone HPLC Assay and Impurity Profiling Methods Following United States Pharmacopeia Monograph Guidelines Using a Titan C18 Column and UV Detection

A simple, precise and sensitive Reverse-Phase High Pressure Liquid Chromatography gradient method was adapted for traceability, homogeneity and total chromatographic analysis of Dexamethasone. The given experimental conditions follow the USP43-NF38 monograph method for Dexamethasone Assay and Organic Impurity Profiling. Dexamethasone, Betamethasone, Dexamethasone acetate and Desoximetasone were baseline resolved within 20 minutes using a Titan C18 UHPLC column (2.1 x 100 mm, 1.9 µm).

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