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Key Documents

PHR1439

Supelco

β-ciclodestrina

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

β-destrina di Schardinger, Carvi, Cicloeptaamilosio, Ciclomaltoeptaosio

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About This Item

Formula empirica (notazione di Hill):
C42H70O35
Numero CAS:
Peso molecolare:
1134.98
Beilstein:
78623
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to USP 1154569

Famiglia di API

cyclodextrin

Saggio

99.9%

Forma fisica

powder

Attività ottica

[α]20/D +162±3°, c = 1.5% in H2O

CdA

current certificate can be downloaded

Classi chimiche degli analiti

oligosaccharides

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

290-300 °C (dec.) (lit.)

applicazioni

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]1[C@H](O)[C@H]2O

InChI

1S/C42H70O35/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51/h8-63H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m1/s1
WHGYBXFWUBPSRW-FOUAGVGXSA-N

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Descrizione generale

Beta-Cyclodextrin is the most abundant and cheap cyclic oligosaccharide that forms inclusion complexes with several drug molecules. Its main application is in tablet and capsule formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Applicazioni

Beta-Cyclodextrin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA2747 in the slot below. This is an example certificate only and may not be the lot that you receive.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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I clienti hanno visto anche

Gamma Cyclodextrin
USP42-NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 33(4), 5692-5692 (2018)
Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, 33(4), 5692-5692 (2009)
H Chen et al.
Se pu = Chinese journal of chromatography, 17(6), 533-538 (2003-01-30)
A review of beta-cyclodextrin bonded stationary phases in chiral liquid chromatography is given, focusing on design and synthesis of beta-cyclodextrin bonded chiral stationary phases. Fifty-three references are presented in this paper.
Nuclear magnetic resonance methods for high molecular weight proteins: a study involving a complex of maltose binding protein and beta-cyclodextrin.
L E Kay
Methods in enzymology, 339, 174-203 (2001-07-21)
Omair Aleem et al.
Journal of pharmaceutical and biomedical analysis, 47(3), 535-540 (2008-03-28)
The solid-state properties, dissolution profile and antimicrobial activity of inclusion complexes of cefdinir (CEF) with beta-cyclodextrin (betaCD) and hydroxypropyl beta-cyclodextrin (HPbetaCD) were investigated. The phase solubility profiles of cefdinir with betaCD and HPbetaCD were classified as A(L)-type, which indicates the

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