MTOX1302

Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells

canine kidney (cocker spaniel)

• Codice UNSPSC: 41106514
• NACRES: NA.81

Proprietà

• Nome del prodotto: Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells,
• Origine biologica: canine kidney (cocker spaniel)
• Stato: liquid
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −196°C
• Informazioni sul gene: human ... ABCG2(9429)

Descrizione

Descrizione generale

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP and Human OATP2B1 has been transfected into the MDCKII cell line. Validation studies have shown BCRP dependent efflux of estrone-3 sulfate (requires OATP2B1) and teriflunomide (does not require OATP2B1).

Caratteristiche e vantaggi

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.

Qualità

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.

Note legali

ADME/Tox Cell Lines License and HepaRG Limited Use License

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable