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Documenti fondamentali

C1909

Sigma-Aldrich

Acido citrico

ACS reagent, ≥99.0%

Sinonimo/i:

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Formula condensata:
HOC(COOH)(CH2COOH)2 · H2O
Numero CAS:
Peso molecolare:
210.14
Beilstein:
4018641
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.21

Grado

ACS reagent

Livello qualitativo

Saggio

≥99.0%

Stato

powder

Impurezze

Substances carbonizable by hot sulfuric acid, passes test
≤0.005% Insoluble matter

Residuo alla calcinazione

≤0.02%

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

Solubilità

H2O: soluble 54 % (w/w) at 10 °C (Citric acid in water)
H2O: 59.2 % (w/w) at 20 °C (Citric acid in water)
H2O: 84.0 % (w/w) at 100 °C (Citric acid in water)

Anioni in tracce

chloride (Cl-): ≤0.001%
oxalate (C2O42-): passes test (limit about 0.05%)
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤0.002%

Cationi in tracce

Fe: ≤3 ppm
Pb: ≤2 ppm

Gruppo funzionale

carboxylic acid

Stringa SMILE

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
YASYEJJMZJALEJ-UHFFFAOYSA-N

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Descrizione generale

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061±123)Jmol-1. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Citric acid monohydrate is an organic weak acid used as a natural preservative in food and beverage products.

Applicazioni

Citric acid monohydrate was used in the preparation of citric acid solution employed in the acetone method of 68Ga pre-purification and radiolabeling technique.
It may be used:
  • As release-modifying agent to improve the release of diltiazem hydrochloride from melt extruded Eudragit RS PO tablets.
  • To prepare citrate buffer for use in the preparation of platelets for intravital microscopy.
  • To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

345.0 °F - closed cup

Punto d’infiammabilità (°C)

173.9 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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Size dependency of citric acid monohydrate growth kinetics.
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Chemical Engineering Journal, 70(3), 203-207 (1998)
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Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)
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Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 76, 46-54 (2012-10-03)
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
New perspectives for citric acid production and application.
Soccol CR, et al.
Food Technology and Biotechnology, 44(2), 141-149 (2006)

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