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Myristoyl-L-carnitine

analytical standard

Sinonimo/i:

(2R)-3-Carboxy-N,N,N-trimethyl-2-[(1-oxotetradecyl)oxy]-1-propanaminium inner salt, L-Carnitine tetradecanoyl ester, C14-Carnitine, Tetradecanoyl-L-carnitine

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About This Item

Formula empirica (notazione di Hill):
C21H41NO4
Numero CAS:
Peso molecolare:
371.55
Beilstein:
4149853
Codice UNSPSC:
41116107
NACRES:
NB.21

Grado

analytical standard

Livello qualitativo

Saggio

≥97.0% (HPLC)

Attività ottica

[α]/D -18.0±2.0°, c = 1 in methanol

Durata

limited shelf life, expiry date on the label

Impurezze

≤10.0% water

applicazioni

clinical testing

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCC)=O)CC([O-])=O

InChI

1S/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
PSHXNVGSVNEJBD-LJQANCHMSA-N

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Descrizione generale

Myristoyl-L-carnitine belongs to the acyl-L-carnitine class of compounds, which are acetylated forms of L-carnitine, derived from the breakdown of amino and fatty acids. The compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency.

Applicazioni

Myristoyl-L-carnitine may be used as an analytical standard to determine the content of the analyte in maize plants using high-performance liquid chromatography coupled to triple quadrupole-LC MS/MS. The exogenous application of carnitine stimulates the transportation of fatty acids into mitochondria, and the possible effect of carnitine on the lipid trafficking between cytoplasm, mitochondrial matrix and the mitochondrial respiration in the leaves of maize grown under normal and cold conditions is investigated.
It may be used as an analytical reference standard in the following:
  • Separation and identification of underivatized myristoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).
  • Determination of the analyte in dried blood samples using high-performance liquid chromatography (HPLC) coupled with electrospray ionization-tandem mass spectrometry (ESI-MS/MS).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable
Matrix effect?corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine
Abe K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 468, 187-194 (2017)
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled
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