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80184

Supelco

Phenylbutazone

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Sinonimo/i:

4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione

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About This Item

Formula empirica (notazione di Hill):
C19H20N2O2
Numero CAS:
50-33-9
Peso molecolare:
308.37
Numero CE:
200-029-0
Numero MDL:
MFCD00005500
Codice UNSPSC:
41116107
ID PubChem:
329768727
NACRES:
NA.24

Grado

certified reference material
TraceCERT®

Livello qualitativo

300

Nome Commerciale

TraceCERT®

Durata

limited shelf life, expiry date on the label

Produttore/marchio commerciale

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

106-108 °C (lit.)

applicazioni

cleaning products
cosmetics
food and beverages
personal care

Formato

neat

Stringa SMILE

CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

InChI

1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
VYMDGNCVAMGZFE-UHFFFAOYSA-N

Informazioni sul gene

human ... PTGS1(5742) , PTGS2(5743)

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Categorie correlate

Descrizione generale

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Note legali

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H312 + H332,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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J Aarbakke
Clinical pharmacokinetics, 3(5), 369-380 (1978-09-01)
More than 25 years after phenylbutazone was introduced as a non-steroidal anti-inflammatory agent, basic knowledge is still accumulating on its pharmacokinetics in man. Phenylbutazone is almost completely absorbed after oral administration. A large fraction of the drug in plasma is
Robert D Combes
Alternatives to laboratory animals : ATLA, 41(3), 235-248 (2013-08-27)
Published in silico, in vitro, in vivo laboratory animal and human data, together with information on biotransformation and data from structure-activity analyses with two decision-tree systems (ACToR and Toxtree), have been used in a weight-of-evidence (WoE) assessment to determine whether
T Tobin et al.
Journal of veterinary pharmacology and therapeutics, 9(1), 1-25 (1986-03-01)
Phenylbutazone is an acidic, lipophilic, non-steroidal anti-inflammatory drug (NSAID). It is extensively metabolized in the horse. The metabolites so far identified, oxyphenbutazone, gamma-hydroxyoxyphenbutazone, account for some 25-30% of administered dose over 24 h. The plasma half-life of phenylbutazone and termination
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
F Tolot et al.
Semaine des hopitaux. Therapeutique, 52(3), 185-190 (1976-03-01)
M Maciazek-Jurczyk et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 1-9 (2009-07-21)
The monitoring of drug concentration in blood serum is necessary in multi-drug therapy. Mechanism of drug binding with serum albumin (SA) is one of the most important factors which determine drug concentration and its transport to the destination tissues. In
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