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00530580

Sennoside B

primary reference standard

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About This Item

Formula empirica (notazione di Hill):
C42H38O20
Numero CAS:
128-57-4
Peso molecolare:
862.74
Beilstein:
5723747
Numero CE:
204-895-0
Numero MDL:
MFCD00151528
Codice UNSPSC:
85151701
ID PubChem:
329747089
NACRES:
NA.24

Grado

primary reference standard

Durata

limited shelf life, expiry date on the label

Produttore/marchio commerciale

HWI

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Stringa SMILE

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26+,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1
IPQVTOJGNYVQEO-OVYIKYHGSA-N

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Descrizione generale

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Applicazioni

Reference standard in the analysis of herbal medicinal products.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
HWI00197-3

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Jin Gyu Choi et al.
Neuroscience letters, 491(2), 93-98 (2011-01-25)
Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investigated the anti-amnesic effects of OSS in a dementia model. Acetylcholinesterase (AChE) inhibition assay was performed
Katsuhiro Yamasaki et al.
Journal of natural medicines, 64(2), 126-132 (2010-01-22)
The sennoside A (SA) and sennoside B (SB) contents of various samples of crude drugs were determined using solid-phase extraction (SPE) and HPLC. The samples examined were crude drugs (senna leaf, senna pods, and rhubarb), conventional crude drug products, and
Meng-Ting Wang et al.
European journal of heart failure, 13(11), 1238-1243 (2011-08-02)
Digoxin is an important medication for heart failure (HF) patients and sennosides are widely used to treat constipation. Recently, safety concerns have been raised about a possible interaction between sennosides and digoxin, an issue that has not been studied empirically.
Kento Takayama et al.
Chemical & pharmaceutical bulletin, 59(9), 1106-1109 (2011-09-02)
Daiokanzoto (DKT, combination of rhubarb and glycyrrhiza), a Kampo medicine, is clinically effective for constipation. Sennoside A is well known to induce diarrhea. Sennoside A is a prodrug that is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. In
Yen-Chun Chen et al.
Life sciences, 84(25-26), 915-922 (2009-04-28)
To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling. Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the
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