AB1593
Anti-Amyloid Precursor Protein Antibody, a.a. 44-63
serum, Chemicon®
Sinonimo/i:
APP
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
human
Produttore/marchio commerciale
Chemicon®
tecniche
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... APP(351)
Specificità
Recognizes amyloid precursor protein (APP). In Alzheimer′s disease, this protein is broken down and releases the 12 amino acid b-amyloid protein that is found in senile plaques and vessels.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
The amyloid precursor protein is the subject of intensive investigations to determine how this protein is broken down abnormally in Alzheimer′s disease to give rise to the b-amyloid protein which is present in senile plaques and vessels. This antiserum has been shown to be immunoreactive to the immunizing peptide by ELISA. The antiserum will immunolabel dystrophic neurites in senile plaques in both formalin-fixed paraffin sections and paraformaldehyde fixed frozen sections from Alzheimer′s brain.
This antiserum should be a valuable tool for scientist and neuropathologists who study the role of amyloid in Alzheimer′s′s disease.
Immunogeno
Epitope: a.a. 44-63
Peptide to the N-terminal region (amino acids 44-63) of the APP protein.
Applicazioni
Anti-Amyloid Precursor Protein Antibody, a.a. 44-63 is an antibody against Amyloid Precursor Protein for use in ELISA, IF, WB, IH, IH(P).
Immunoblotting: 1:1,000
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Immunofluorescence
Immunohistochemistry
Formalin fixed paraffin embedded tissue:1:50-1:100
4% paraformaldehyde fixed frozen sections: 1:2,500-1:5,000
ELISA: 1:1,500 against immunogen peptide
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Stato fisico
Goat antiserum. Liquid with 0.1% Sodium Azide
Stoccaggio e stabilità
Store at -20ºC in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques.
Palmert, M R, et al.
Biochemical and biophysical research communications, 156, 432-437 (1988)
Grant T Corbett et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8445-8450 (2015-06-17)
Amyloid precursor protein (APP) derivative β-amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Sequential proteolysis of APP by β-secretase and γ-secretase generates Aβ. Conversely, the α-secretase "a disintegrin and metalloproteinase" 10 (ADAM10) cleaves APP within
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