566322-M

SIRT1 Inhibitor III

The SIRT1 Inhibitor III, also referenced under CAS 49843-98-3, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Sinonimo/i: SIRT1 Inhibitor III, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527
• Formula empirica (notazione di Hill): C₁₃H₁₃ClN₂O
• Numero CAS: 49843-98-3
• Peso molecolare: 248.71
• Numero MDL: MFCD03009471
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: off-white
• Solubilità: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Clc1cc2c([nH]c3c2CCCC3C(=O)N)cc1
• InChI: 1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17); FUZYTVDVLBBXDL-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC₅₀ = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC₅₀ = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo.

Azioni biochim/fisiol

Primary Target
SIRT1

Target IC₅₀: 98 nM against SIRT1

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Solomon, J.M., et al. 2006. Mol. Cell. Biol.26, 28.
Napper, A.D., et al. 2005. J. Med. Chem.48, 8045.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3