475870
MnTBAP
≥95% (TLC), solid, SOD mimetic, Calbiochem®
Sinonimo/i:
MnTBAP, Mn(III)tetrakis(4-benzoic acid)porphyrin Chloride
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About This Item
Formula empirica (notazione di Hill):
C48H28ClMnN4O8
Numero CAS:
Peso molecolare:
879.15
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
product name
MnTBAP, Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
Livello qualitativo
Saggio
≥95% (TLC)
Forma fisica
solid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
desiccated
protect from light
Colore
brown
Solubilità
aqueous base: soluble
Condizioni di spedizione
ambient
Temperatura di conservazione
−20°C
Descrizione generale
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).
Azioni biochim/fisiol
Cell permeable: yes
EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Primary Target
Superoxide dismutase (SOD) mimetic
Superoxide dismutase (SOD) mimetic
Product does not compete with ATP.
Reversible: no
Attenzione
Toxicity: Standard Handling (A)
Ricostituzione
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Altre note
Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I clienti hanno visto anche
M A Aladag et al.
Acta neurochirurgica, 145(8), 673-677 (2003-10-02)
Delayed cerebral vasoconstriction and brain ischemia, are critical problems in the management of a patient affected by rupture of an intracranial aneurysm. Overexpression of Cu-Zn superoxide dismutase (Cu-Zn SOD) can reduce the extent of cerebral vasospasm. We, therefore investigated if
K M Faulkner et al.
The Journal of biological chemistry, 269(38), 23471-23476 (1994-09-23)
Several manganic porphyrins, with substituents on the methine bridge carbons, were prepared and examined for stability, redox behavior, catalysis of the dismutation of superoxide radical (O2-), and the ability to protect a superoxide dismutase (SOD)-null strain of E. coli against
C Szabó et al.
FEBS letters, 381(1-2), 82-86 (1996-02-26)
Here we report that the cell-permeable superoxide dismutase mimetic Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP) inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO). MnTBAP protects against the suppression of mitochondrial respiration in J774 cells exposed
B J Day et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1227-1232 (1995-12-01)
There is an increased interest in development of therapeutic agents to treat disease states that involve reactive oxygen species in their pathophysiology. The metalloporphyrins, MnTBAP and ZnTBAP, were found to be active in a superoxide dismutase (SOD) assay. The efficacy
Maria Catalina Gomez-Puerto et al.
International journal of molecular sciences, 21(11) (2020-06-14)
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by obstructed pulmonary vasculatures. Current therapies for PAH are limited and only alleviate symptoms. Reduced levels of BMPR2 are associated with PAH pathophysiology. Moreover, reactive oxygen species, inflammation and autophagy have
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