A8674

Antimycin A from Streptomyces sp.

• Sinonimo/i: Antipiricullin
• Numero CAS: 1397-94-0
• Numero MDL: MFCD01779723
• Codice UNSPSC: 12352200
• ID PubChem: 24891355
• NACRES: NA.77

Proprietà

• Forma fisica: powder
• Livello qualitativo: 300
• Spettro attività antibiotica: fungi
• Modalità d’azione: enzyme | inhibits
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
• InChI: 1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1; UIFFUZWRFRDZJC-RBVQMQRASA-N

Descrizione

Descrizione generale

Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation.

Chemical structure: peptide

Applicazioni

Antimycin A from Streptomyces sp. has been used:

• as a respiratory chain inhibitor in neuronal cultures
• in organello ATP production assay in Trypanosoma brucei cells
• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Azioni biochim/fisiol

Inhibitor of electron transfer at complex III. Induces apoptosis.

Qualità

A mixture of antimycins.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H400
• Consigli di prudenza: P264 - P273 - P301 + P310 - P391 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral - Aquatic Acute 1
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges