474788

MG-132

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem^®

• Sinonimo/i: InSolution MG-132 in EtOH, ≥95% by HPLC, Proteasome Inhibitor XI
• Formula empirica (notazione di Hill): C₂₆H₄₁N₃O₅
• Peso molecolare: 475.62
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: MG-132 in EtOH, ≥95% by HPLC, InSolution, ≥95%, reversible proteasome inhibitor
• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM).Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κBactivation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.

Azioni biochim/fisiol

Cell permeable: yes

K_i = 4 nM for proteasomal inhibition

Reversible: yes

Secondary Target
IKK

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Flammable (J)

Ricostituzione

Following initital thaw, aliquot and freeze (-70°C).

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H319
• Consigli di prudenza: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Flam. Liq. 2
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): 53.6 °F - closed cup - Information refers to the main ingredient.
• Punto d’infiammabilità (°C): 12 °C - closed cup - Information refers to the main ingredient.