M8699
(R)-MG132
Sinonimo/i:
Z-L-Leu-D-Leu-L-Leu-al
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About This Item
Formula empirica (notazione di Hill):
C26H41N3O5
Numero CAS:
Peso molecolare:
475.62
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Saggio
≥98%
Livello qualitativo
Solubilità
DMSO or DMF: 25 mg/mL
Temperatura di conservazione
−20°C
Stringa SMILE
CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
Applicazioni
(R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Azioni biochim/fisiol
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
Stato fisico
crystalline solid or supercooled liquid
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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MG-132 is a tripeptide aldehyde (Z-l-leu-l-leu-l-leu-H, 2) proteasome inhibitor that exerts antitumor activity and enhances cytostatic/cytotoxic effects of chemo- and radiotherapy. Because of a troublesome synthesis of tripeptides with a non-natural configuration and modified side chains of amino acids, only
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